The iconic Hooper-Lee-Nichols House, a landmark of extraordinary provenance, built circa 1685 and recognized as the second-oldest home in Cambridge, now seeks its next chapter. This remarkable residence has endured for more than three centuries and has evolved through successive architectural periods. Today it stands as the headquarters of History Cambridge and a living treasure — a testament to early American design. The three-story Georgian structure, distinguished by its central chimney and balanced proportions, encompasses approximately 6,449± square feet. Set on an expansive 18,012± square foot corner parcel at Brattle Street and Kennedy Road, the house is positioned well back from the street with a detached carriage house/garage accessed from quiet Kennedy Road. Though it is currently configured for office use, future owners will have the opportunity to reimagine the interiors as a grand private home. The property is protected by historic preservation measures ensuring its integrity for generations to come. An easement held by the Massachusetts Historical Commission safeguards important interior features, while its location within the Old Cambridge Historic District places exterior alterations under review by the Cambridge Historical Commission. The Hooper-Lee-Nichols House is more than a distinguished address. It is an invitation to stewardship—an opportunity to carry forward a 340-year legacy in one of America’s most historic settings.